Motif ID: RXR{A,B,G}.p2

Z-value: 1.642


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRBchr6_-_331684480.492.8e-14Click!
RXRGchr1_-_1654144990.152.3e-02Click!
RXRAchr9_+_1372183130.092.0e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_70288155 26.298 NM_013346
SNX12
sorting nexin 12
chr1_+_6845381 22.955 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr17_-_62833225 21.723 PLEKHM1P
pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr19_-_1174257 21.269 SBNO2
strawberry notch homolog 2 (Drosophila)
chr14_-_103988829 20.713 CKB
creatine kinase, brain
chr18_-_51750460 18.719 MBD2
methyl-CpG binding domain protein 2
chr8_-_70983549 18.702 NM_024504
PRDM14
PR domain containing 14
chr2_+_230787195 17.197 NM_174899
FBXO36
F-box protein 36
chr14_+_101193275 16.628 DLK1
delta-like 1 homolog (Drosophila)
chr22_+_19701968 16.386 NM_002688
SEPT5
septin 5
chr8_-_70983468 15.633 PRDM14
PR domain containing 14
chr15_+_62682682 15.304 TLN2
talin 2
chr17_-_27278324 15.213 PHF12
PHD finger protein 12
chr14_-_103989195 14.973 NM_001823
CKB
creatine kinase, brain
chr17_-_15902907 14.908 NM_001042697
NM_001042698
ZSWIM7

zinc finger, SWIM-type containing 7

chr19_-_36246411 14.403 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr22_-_44258210 14.246 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chrX_-_51239426 14.241 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr19_-_1174263 14.180 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr19_-_14228560 14.143 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr20_-_44539597 14.061 NM_001242921
PLTP
phospholipid transfer protein
chr5_+_149865310 13.948 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr17_+_3627133 13.838 NM_031965
GSG2
germ cell associated 2 (haspin)
chr16_+_22825806 13.769 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr15_-_76030958 13.719 DNM1P35
DNM1 pseudogene 35
chr22_-_19511777 13.507 CLDN5
claudin 5
chr16_+_58497993 13.503 NM_001130487
NDRG4
NDRG family member 4
chr1_-_38512446 13.010 NM_002699
POU3F1
POU class 3 homeobox 1
chr2_+_27301693 12.939 EMILIN1
elastin microfibril interfacer 1
chr19_+_7968774 12.781 MAP2K7
mitogen-activated protein kinase kinase 7
chr19_-_14228362 12.471 NM_002730
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr3_+_133465250 12.294 TF
transferrin
chr3_+_133465098 12.277 TF
transferrin
chr3_-_14988976 12.052 LOC100505641
uncharacterized LOC100505641
chr3_+_133465204 11.972 TF
transferrin
chr19_-_56632644 11.915 NM_001002836
ZNF787
zinc finger protein 787
chr3_+_49591897 11.857 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chr11_+_118401873 11.616 TMEM25
transmembrane protein 25
chrX_+_38420690 11.548 NM_004615
TSPAN7
tetraspanin 7
chr16_+_58498182 11.386 NDRG4
NDRG family member 4
chr17_+_74733468 11.299 NM_001242532
NM_001242533
NM_001242535
NM_001242536
NM_001242537
NM_024311
MFSD11





major facilitator superfamily domain containing 11





chr17_-_72889704 11.296 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr20_-_44539542 11.272 PLTP
phospholipid transfer protein
chr14_-_81687265 11.260 NM_015859
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr19_+_7968762 11.237 MAP2K7
mitogen-activated protein kinase kinase 7
chr3_-_14988939 11.123 LOC100505641
uncharacterized LOC100505641
chr11_+_62439120 11.079 NM_001085372
C11orf83
chromosome 11 open reading frame 83
chr19_-_36246206 11.051 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr6_-_34664517 11.026 C6orf106
chromosome 6 open reading frame 106
chr17_+_38119225 11.024 NM_178171
GSDMA
gasdermin A
chr11_+_62439134 10.959 C11orf83
chromosome 11 open reading frame 83
chr12_-_54982271 10.954 NM_006741
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr19_+_58095507 10.815 NM_001010879
ZIK1
zinc finger protein interacting with K protein 1 homolog (mouse)
chr19_+_7968820 10.574 MAP2K7
mitogen-activated protein kinase kinase 7
chr10_-_81205091 10.542 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr8_-_57359148 10.488 NM_001135690
PENK
proenkephalin
chr14_+_101193190 10.412 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr19_+_50354368 10.345 NM_017432
PTOV1
prostate tumor overexpressed 1
chr19_-_38720312 10.274 NM_001135156
DPF1
D4, zinc and double PHD fingers family 1
chr1_+_202317798 10.198 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr9_+_74526527 10.182 C9orf85
chromosome 9 open reading frame 85
chr14_-_58764805 10.126 FLJ31306
uncharacterized LOC379025
chr16_+_2653350 10.103 LOC652276
potassium channel tetramerisation domain containing 5 pseudogene
chr19_+_47759730 10.048 NM_015603
CCDC9
coiled-coil domain containing 9
chr19_+_7968765 10.023 MAP2K7
mitogen-activated protein kinase kinase 7
chr19_+_16999871 9.997 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr17_-_4046298 9.975 ZZEF1
zinc finger, ZZ-type with EF-hand domain 1
chr4_-_8873453 9.878 NM_018942
HMX1
H6 family homeobox 1
chr12_-_133532847 9.826 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chrX_-_17879355 9.814 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr16_+_22825481 9.688 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr3_+_133464883 9.686 NM_001063
TF
transferrin
chr22_+_19705891 9.577 NM_001009939
SEPT5
septin 5
chr19_+_7968701 9.554 MAP2K7
mitogen-activated protein kinase kinase 7
chrX_-_51239295 9.525 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chrX_+_101380659 9.511 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr17_+_7554711 9.510 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr7_+_94023872 9.289 NM_000089
COL1A2
collagen, type I, alpha 2
chr19_+_7968764 9.254 NM_145185
MAP2K7
mitogen-activated protein kinase kinase 7
chr1_+_44412418 9.087 NM_014652
IPO13
importin 13
chr7_+_94024201 9.080 COL1A2
collagen, type I, alpha 2
chr7_+_30068206 8.944 PLEKHA8P1
PLEKHA8
pleckstrin homology domain containing, family A member 8 pseudogene 1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
chr11_+_64067862 8.911 NM_001039496
C11orf20
chromosome 11 open reading frame 20
chr7_-_35734472 8.876 HERPUD2
HERPUD family member 2
chr17_+_7184978 8.814 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr9_+_103235634 8.747 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr11_+_113931228 8.736 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr3_-_28390280 8.690 AZI2
5-azacytidine induced 2
chr6_-_132272311 8.686 NM_001901
CTGF
connective tissue growth factor
chr1_+_44412582 8.655 IPO13
importin 13
chr19_+_47759802 8.636 CCDC9
coiled-coil domain containing 9
chr16_+_2039945 8.619 NM_004209
SYNGR3
synaptogyrin 3
chr17_-_62833246 8.607 PLEKHM1P
pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr12_+_52345467 8.584 ACVR1B
activin A receptor, type IB
chr7_+_100136845 8.576 AGFG2
ArfGAP with FG repeats 2
chr11_-_118661826 8.575 DDX6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr11_+_61197574 8.568 NM_017841
SDHAF2
succinate dehydrogenase complex assembly factor 2
chr14_+_101193313 8.562 DLK1
delta-like 1 homolog (Drosophila)
chr10_-_73848263 8.549 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_-_35734728 8.507 HERPUD2
HERPUD family member 2
chr19_+_18723666 8.483 NM_012109
TMEM59L
transmembrane protein 59-like
chr1_-_57888785 8.472 DAB1
disabled homolog 1 (Drosophila)
chr17_-_1532109 8.441 NM_152346
SLC43A2
solute carrier family 43, member 2
chr19_+_50353942 8.305 PTOV1
prostate tumor overexpressed 1
chr6_+_89791510 8.292 PNRC1
proline-rich nuclear receptor coactivator 1
chr5_-_43412417 8.267 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr19_-_18548971 8.239 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr22_-_51016343 8.222 NM_001145137
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr9_-_139094886 8.211 NM_014564
LHX3
LIM homeobox 3
chr7_-_35734762 8.208 NM_022373
HERPUD2
HERPUD family member 2
chr7_-_124405029 8.193 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr15_+_63569748 8.171 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr17_-_62833264 8.130 PLEKHM1P
pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr8_+_27631902 8.098 NM_001017420
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr6_+_126112057 8.090 NCOA7
nuclear receptor coactivator 7
chr19_+_50354417 8.083 PTOV1
prostate tumor overexpressed 1
chr16_+_55542909 8.041 NM_017839
LPCAT2
lysophosphatidylcholine acyltransferase 2
chr20_+_44657858 8.040 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr22_-_29784568 8.012 NM_001127
NM_001166019
NM_145730
AP1B1


adaptor-related protein complex 1, beta 1 subunit


chr1_-_156399183 7.955 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr6_+_35227478 7.935 NM_003427
ZNF76
zinc finger protein 76
chr2_+_241938254 7.913 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr3_-_139258531 7.903 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr1_+_44412640 7.886 IPO13
importin 13
chr6_+_43738757 7.804 VEGFA
vascular endothelial growth factor A
chr5_+_74807580 7.779 NM_016218
POLK
polymerase (DNA directed) kappa
chr16_+_69984809 7.746 NM_182619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr3_-_28390506 7.723 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr22_-_29784430 7.711 AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr11_+_62380212 7.710 NM_000327
ROM1
retinal outer segment membrane protein 1
chrY_-_15591799 7.695 UTY
ubiquitously transcribed tetratricopeptide repeat gene, Y-linked
chr16_+_58497628 7.694 NDRG4
NDRG family member 4
chr17_-_1531543 7.683 SLC43A2
solute carrier family 43, member 2
chr12_-_53448167 7.673 LOC283335
uncharacterized LOC283335
chr12_-_48152180 7.649 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr17_+_42264300 7.642 NM_001076674
NM_024107
TMUB2

transmembrane and ubiquitin-like domain containing 2

chr11_-_2162340 7.596 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr10_-_26986553 7.586


chr3_-_14989399 7.542 LOC100505641
uncharacterized LOC100505641
chr15_-_71146427 7.526 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr9_-_110251754 7.446 KLF4
Kruppel-like factor 4 (gut)
chr22_-_19512001 7.440 CLDN5
claudin 5
chr20_+_44657812 7.413 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr16_+_70148213 7.379 PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr22_+_24373107 7.377 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chr9_-_133454818 7.375 LOC100272217
uncharacterized LOC100272217
chr9_+_103235489 7.364 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr3_-_48885028 7.348 PRKAR2A
protein kinase, cAMP-dependent, regulatory, type II, alpha
chr17_+_42264582 7.327 TMUB2
transmembrane and ubiquitin-like domain containing 2
chr7_+_97910978 7.304 NM_001159491
NM_015379
BRI3

brain protein I3

chr6_-_46459010 7.293 NM_001251974
RCAN2
regulator of calcineurin 2
chr2_+_105471745 7.284 NM_006236
POU3F3
POU class 3 homeobox 3
chr22_+_19705990 7.244 SEPT5-GP1BB
SEPT5-GP1BB readthrough
chr14_-_103989112 7.195 CKB
creatine kinase, brain
chr19_+_56186426 7.182 NM_001130072
NM_013333
EPN1

epsin 1

chr17_+_72920369 7.138 NM_178160
OTOP2
otopetrin 2
chr19_-_49658645 7.073 NM_002152
HRC
histidine rich calcium binding protein
chr11_-_118661856 7.070 DDX6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr3_+_50306578 7.050 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr12_+_58013692 7.048 NM_133489
SLC26A10
solute carrier family 26, member 10
chr19_-_4723791 7.037 DPP9
dipeptidyl-peptidase 9
chr8_-_26371387 7.000 NM_007257
PNMA2
paraneoplastic antigen MA2
chr7_-_3083346 6.922 NM_032415
CARD11
caspase recruitment domain family, member 11
chrX_+_55478537 6.824 NM_014061
MAGEH1
melanoma antigen family H, 1
chr2_+_27274520 6.823 AGBL5
ATP/GTP binding protein-like 5
chr14_+_29236882 6.808 FOXG1
forkhead box G1
chr20_-_23402038 6.766 NM_022080
NAPB
N-ethylmaleimide-sensitive factor attachment protein, beta
chr22_-_20104695 6.757 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr11_+_125774271 6.754 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr17_-_4046190 6.731


chr11_+_450346 6.715 PTDSS2
phosphatidylserine synthase 2
chr14_-_21493910 6.699 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr17_-_46688279 6.671 HOXB7
homeobox B7
chr17_+_42264573 6.664 NM_177441
TMUB2
transmembrane and ubiquitin-like domain containing 2
chr2_-_103353300 6.657 NM_032718
MFSD9
major facilitator superfamily domain containing 9
chrX_+_135229536 6.652 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr1_+_7844713 6.610 NM_016831
PER3
period homolog 3 (Drosophila)
chr19_+_39390570 6.598 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr13_+_37006628 6.589 CCNA1
cyclin A1
chr20_+_44650260 6.585 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr22_-_51021200 6.585 CHKB
choline kinase beta
chr19_-_39390168 6.578 NM_012237
NM_001193286
NM_030593
SIRT2


sirtuin 2


chr12_-_42631982 6.575 NM_001190977
YAF2
YY1 associated factor 2
chr11_+_450260 6.571 NM_030783
PTDSS2
phosphatidylserine synthase 2
chr16_+_58497548 6.565 NM_020465
NDRG4
NDRG family member 4
chr19_-_18548788 6.546 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr22_-_20104745 6.535 NM_022727
NM_182984
TRMT2A

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)

chr1_+_183774214 6.533 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr6_+_117002349 6.527 NM_002269
KPNA5
karyopherin alpha 5 (importin alpha 6)
chr14_-_23834417 6.523 EFS
embryonal Fyn-associated substrate
chr1_+_19971865 6.517 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr19_+_45754551 6.498 MARK4
MAP/microtubule affinity-regulating kinase 4
chr19_+_52873169 6.483 NM_001145434
ZNF880
zinc finger protein 880
chr5_+_173472692 6.481 NM_015980
HMP19
HMP19 protein
chr19_-_6279797 6.438


chr22_+_38035718 6.428 SH3BP1
SH3-domain binding protein 1
chr8_+_26371461 6.408 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr19_-_12595625 6.391 NM_152601
ZNF709
zinc finger protein 709
chr11_-_118661898 6.365 NM_004397
DDX6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr10_-_75910525 6.332 NM_012095
NM_207012
AP3M1

adaptor-related protein complex 3, mu 1 subunit


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.51 8.72e-20 GO:0048856 anatomical structure development
1.43 3.42e-18 GO:0032502 developmental process
1.51 1.01e-17 GO:0048731 system development
1.75 4.24e-17 GO:0009653 anatomical structure morphogenesis
1.24 7.30e-17 GO:0065007 biological regulation
1.44 2.60e-16 GO:0007275 multicellular organismal development
1.15 1.52e-15 GO:0009987 cellular process
1.40 6.16e-15 GO:0023052 signaling
1.56 1.34e-13 GO:0030154 cell differentiation
1.24 2.67e-13 GO:0050794 regulation of cellular process
1.23 3.48e-13 GO:0050789 regulation of biological process
1.53 7.38e-13 GO:0048869 cellular developmental process
1.65 7.94e-13 GO:0007399 nervous system development
1.29 2.20e-12 GO:0032501 multicellular organismal process
1.60 5.14e-12 GO:0023051 regulation of signaling
1.67 2.11e-11 GO:0051239 regulation of multicellular organismal process
1.79 9.60e-11 GO:0050793 regulation of developmental process
1.36 1.09e-10 GO:0007165 signal transduction
1.76 8.81e-10 GO:0048468 cell development
1.84 1.33e-09 GO:2000026 regulation of multicellular organismal development
1.49 2.44e-09 GO:0048513 organ development
1.58 3.23e-09 GO:0009966 regulation of signal transduction
1.73 7.15e-09 GO:0022008 neurogenesis
1.75 7.63e-09 GO:0048699 generation of neurons
1.29 8.30e-09 GO:0051716 cellular response to stimulus
1.87 1.50e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.66 1.77e-08 GO:0010646 regulation of cell communication
1.68 2.07e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.82 6.71e-08 GO:0045595 regulation of cell differentiation
1.46 7.61e-08 GO:0048583 regulation of response to stimulus
1.80 8.14e-08 GO:0030182 neuron differentiation
1.98 1.34e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.41 2.66e-07 GO:0006355 regulation of transcription, DNA-dependent
1.63 3.23e-07 GO:0007154 cell communication
1.35 5.08e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 5.08e-07 GO:0031326 regulation of cellular biosynthetic process
1.35 6.04e-07 GO:0009889 regulation of biosynthetic process
1.35 7.46e-07 GO:0048518 positive regulation of biological process
1.36 7.95e-07 GO:0010468 regulation of gene expression
1.72 1.04e-06 GO:0007267 cell-cell signaling
1.36 1.51e-06 GO:0048522 positive regulation of cellular process
1.81 1.64e-06 GO:0009887 organ morphogenesis
1.38 2.26e-06 GO:0051252 regulation of RNA metabolic process
1.39 2.28e-06 GO:0048523 negative regulation of cellular process
1.82 2.43e-06 GO:0048666 neuron development
1.74 3.32e-06 GO:0010628 positive regulation of gene expression
2.03 3.57e-06 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.10 4.01e-06 GO:0051093 negative regulation of developmental process
1.35 4.47e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.36 4.98e-06 GO:0048519 negative regulation of biological process
1.78 5.09e-06 GO:0000902 cell morphogenesis
2.76 6.62e-06 GO:0001503 ossification
1.63 7.02e-06 GO:0006351 transcription, DNA-dependent
1.88 8.04e-06 GO:0072358 cardiovascular system development
1.88 8.04e-06 GO:0072359 circulatory system development
1.84 1.08e-05 GO:0000904 cell morphogenesis involved in differentiation
2.07 1.18e-05 GO:0001501 skeletal system development
1.74 1.29e-05 GO:0032989 cellular component morphogenesis
1.27 1.37e-05 GO:0080090 regulation of primary metabolic process
1.32 1.38e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.27 1.56e-05 GO:0031323 regulation of cellular metabolic process
1.90 1.63e-05 GO:0032583 regulation of gene-specific transcription
2.08 1.65e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.34 1.74e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.57 2.01e-05 GO:0032879 regulation of localization
1.28 2.07e-05 GO:0060255 regulation of macromolecule metabolic process
1.25 2.08e-05 GO:0019222 regulation of metabolic process
1.81 2.50e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.56 2.71e-05 GO:0009605 response to external stimulus
1.35 3.81e-05 GO:0042221 response to chemical stimulus
1.95 3.94e-05 GO:0048598 embryonic morphogenesis
1.86 4.30e-05 GO:0048812 neuron projection morphogenesis
1.71 5.45e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.81 5.77e-05 GO:0031175 neuron projection development
1.67 5.98e-05 GO:0009790 embryo development
1.85 6.12e-05 GO:0051094 positive regulation of developmental process
1.71 7.69e-05 GO:0010629 negative regulation of gene expression
1.58 8.44e-05 GO:0009888 tissue development
1.85 8.77e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.63 9.45e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.78 1.03e-04 GO:0032990 cell part morphogenesis
1.26 1.05e-04 GO:0051179 localization
1.74 1.19e-04 GO:0051253 negative regulation of RNA metabolic process
2.50 1.35e-04 GO:0001655 urogenital system development
1.77 1.38e-04 GO:0048858 cell projection morphogenesis
2.09 1.53e-04 GO:0045596 negative regulation of cell differentiation
1.74 1.71e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.17 1.72e-04 GO:0050896 response to stimulus
1.75 2.33e-04 GO:0007417 central nervous system development
1.58 2.62e-04 GO:0051128 regulation of cellular component organization
1.96 3.36e-04 GO:0060284 regulation of cell development
1.93 3.50e-04 GO:0007411 axon guidance
1.77 4.87e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.63 5.09e-04 GO:0009719 response to endogenous stimulus
1.42 5.56e-04 GO:0035556 intracellular signal transduction
2.02 6.75e-04 GO:0001568 blood vessel development
1.64 7.26e-04 GO:0030030 cell projection organization
1.80 7.50e-04 GO:0007409 axonogenesis
1.36 7.70e-04 GO:0007166 cell surface receptor linked signaling pathway
1.50 1.05e-03 GO:0032774 RNA biosynthetic process
1.64 1.13e-03 GO:0009725 response to hormone stimulus
1.64 1.13e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.11 1.21e-03 GO:0048514 blood vessel morphogenesis
1.53 1.27e-03 GO:0040011 locomotion
1.93 1.30e-03 GO:0051130 positive regulation of cellular component organization
2.09 1.40e-03 GO:0048011 nerve growth factor receptor signaling pathway
2.40 1.45e-03 GO:0050678 regulation of epithelial cell proliferation
1.94 1.62e-03 GO:0001944 vasculature development
1.31 1.77e-03 GO:0065008 regulation of biological quality
1.59 1.81e-03 GO:0031327 negative regulation of cellular biosynthetic process
2.34 1.88e-03 GO:0045165 cell fate commitment
1.62 2.07e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.59 2.17e-03 GO:0051254 positive regulation of RNA metabolic process
1.52 2.20e-03 GO:0009891 positive regulation of biosynthetic process
1.52 2.47e-03 GO:0031328 positive regulation of cellular biosynthetic process
2.57 2.68e-03 GO:0048736 appendage development
2.57 2.68e-03 GO:0060173 limb development
1.73 2.74e-03 GO:0010648 negative regulation of cell communication
1.78 2.84e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.61 2.91e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.54 3.34e-03 GO:0072001 renal system development
2.58 3.64e-03 GO:0035107 appendage morphogenesis
2.58 3.64e-03 GO:0035108 limb morphogenesis
1.25 3.78e-03 GO:0051234 establishment of localization
1.25 3.93e-03 GO:0006810 transport
3.21 4.02e-03 GO:0010810 regulation of cell-substrate adhesion
1.90 4.16e-03 GO:0051270 regulation of cellular component movement
1.53 4.21e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.54 4.46e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.72 4.89e-03 GO:0023057 negative regulation of signaling
1.99 4.98e-03 GO:0040007 growth
1.56 5.11e-03 GO:0009890 negative regulation of biosynthetic process
1.23 5.24e-03 GO:0016043 cellular component organization
2.22 5.72e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.82 7.10e-03 GO:0032535 regulation of cellular component size
1.57 7.59e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.93 7.80e-03 GO:0030334 regulation of cell migration
1.73 8.03e-03 GO:0009968 negative regulation of signal transduction
1.88 8.13e-03 GO:0040012 regulation of locomotion
1.78 8.35e-03 GO:0007420 brain development
2.58 8.39e-03 GO:0030198 extracellular matrix organization
1.81 8.89e-03 GO:0045597 positive regulation of cell differentiation
2.34 1.11e-02 GO:0022604 regulation of cell morphogenesis
1.91 1.14e-02 GO:2000145 regulation of cell motility
1.64 1.31e-02 GO:0019226 transmission of nerve impulse
1.64 1.31e-02 GO:0035637 multicellular organismal signaling
2.57 1.43e-02 GO:0051216 cartilage development
2.47 1.46e-02 GO:0001822 kidney development
1.90 1.55e-02 GO:0008361 regulation of cell size
2.30 1.61e-02 GO:0048705 skeletal system morphogenesis
1.40 1.64e-02 GO:0010604 positive regulation of macromolecule metabolic process
2.78 1.81e-02 GO:2000027 regulation of organ morphogenesis
1.67 1.82e-02 GO:0046903 secretion
3.25 2.07e-02 GO:0001649 osteoblast differentiation
2.18 2.08e-02 GO:0043062 extracellular structure organization
2.99 2.39e-02 GO:0050680 negative regulation of epithelial cell proliferation
5.99 2.61e-02 GO:0051893 regulation of focal adhesion assembly
5.99 2.61e-02 GO:0090109 regulation of cell-substrate junction assembly
2.28 2.65e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.84 2.83e-02 GO:0035295 tube development
1.50 2.98e-02 GO:0051049 regulation of transport
2.52 3.02e-02 GO:0030326 embryonic limb morphogenesis
2.52 3.02e-02 GO:0035113 embryonic appendage morphogenesis
1.91 3.14e-02 GO:0006897 endocytosis
1.91 3.14e-02 GO:0010324 membrane invagination
2.07 3.30e-02 GO:0030900 forebrain development
1.78 3.38e-02 GO:0032870 cellular response to hormone stimulus
1.60 3.66e-02 GO:0006935 chemotaxis
1.60 3.66e-02 GO:0042330 taxis
1.20 3.70e-02 GO:0071840 cellular component organization or biogenesis
1.75 3.73e-02 GO:0071495 cellular response to endogenous stimulus
2.50 3.74e-02 GO:0040013 negative regulation of locomotion
1.42 4.15e-02 GO:0042127 regulation of cell proliferation
1.70 4.16e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.60 4.38e-02 GO:0048585 negative regulation of response to stimulus
1.64 4.46e-02 GO:0007268 synaptic transmission
1.68 4.70e-02 GO:0007264 small GTPase mediated signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.39 5.66e-08 GO:0044459 plasma membrane part
1.90 3.37e-06 GO:0045202 synapse
1.44 5.01e-05 GO:0031226 intrinsic to plasma membrane
1.81 8.68e-05 GO:0043005 neuron projection
1.43 1.32e-04 GO:0005887 integral to plasma membrane
1.79 2.97e-04 GO:0031012 extracellular matrix
1.41 1.29e-03 GO:0000267 cell fraction
2.12 2.59e-03 GO:0030136 clathrin-coated vesicle
1.46 3.60e-03 GO:0005626 insoluble fraction
1.96 5.44e-03 GO:0030135 coated vesicle
2.31 6.04e-03 GO:0044420 extracellular matrix part
2.70 7.43e-03 GO:0005604 basement membrane
1.43 8.03e-03 GO:0042995 cell projection
1.73 8.76e-03 GO:0005578 proteinaceous extracellular matrix
1.44 1.33e-02 GO:0031982 vesicle
1.96 1.43e-02 GO:0031252 cell leading edge
1.43 1.92e-02 GO:0031410 cytoplasmic vesicle
1.44 1.92e-02 GO:0031988 membrane-bounded vesicle
1.42 1.95e-02 GO:0005624 membrane fraction
1.72 2.19e-02 GO:0044456 synapse part
1.43 3.45e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.63 3.70e-02 GO:0048471 perinuclear region of cytoplasm
3.24 3.76e-02 GO:0005581 collagen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.68 1.42e-09 GO:0001071 nucleic acid binding transcription factor activity
1.68 1.42e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.76 1.02e-07 GO:0043565 sequence-specific DNA binding
1.56 2.58e-06 GO:0030528 transcription regulator activity
1.15 2.78e-05 GO:0005515 protein binding
2.92 2.27e-04 GO:0005201 extracellular matrix structural constituent
1.29 3.64e-04 GO:0003677 DNA binding
1.07 7.48e-04 GO:0005488 binding
1.81 2.20e-03 GO:0016563 transcription activator activity
3.16 2.37e-03 GO:0004879 ligand-dependent nuclear receptor activity
3.17 4.10e-03 GO:0003707 steroid hormone receptor activity
2.43 7.47e-03 GO:0005057 receptor signaling protein activity
1.96 7.84e-03 GO:0000975 regulatory region DNA binding
1.96 7.84e-03 GO:0001067 regulatory region nucleic acid binding
1.96 7.84e-03 GO:0044212 transcription regulatory region DNA binding
2.09 8.29e-03 GO:0005085 guanyl-nucleotide exchange factor activity
3.19 1.23e-02 GO:0046332 SMAD binding
1.73 2.78e-02 GO:0005083 small GTPase regulator activity
1.71 3.20e-02 GO:0016564 transcription repressor activity
1.90 3.28e-02 GO:0010843 promoter binding
2.37 3.51e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.56 3.68e-02 GO:0060589 nucleoside-triphosphatase regulator activity
5.72 3.90e-02 GO:0048185 activin binding
1.56 4.41e-02 GO:0030695 GTPase regulator activity
1.60 4.41e-02 GO:0022838 substrate-specific channel activity
1.60 4.82e-02 GO:0005216 ion channel activity